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, Combating multidrug resistance and metastasis of breast cancer by endoplasmic reticulum stress and cell-nucleus penetration enhanced immunochemotherapy
On 21 March 2022, Jianli Ren, Department of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging, the Second Affiliated Hospital of Chongqing Medical University, P. R. China, and his team published a paper tittled “Combating multidrug resistance and metastasis of breast cancer by endoplasmic reticulum stress and cell-nucleus penetration enhanced immunochemotherapy” in Theranostics, which presented a nanocomposite that can restrict the growth of drug-resistant breast tumors and activates a strong immune response as well.The kits [ELISA Kit for Tumor Necrosis Factor Alpha (TNFa), SEA133Mu; ELISA Kit for Interferon Gamma (IFNg), SEA049Mu; ELISA Kit for Interleukin 6 (IL......
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, New findings from schizophrenia gene study
Schizophrenia is a severe psychiatric disorder with signs and symptoms that includehallucinations, delusions, disorganized speech and behaviour, diminished emotional expression, social withdrawal and cognitive impairment, typically manifests in late adolescence or early adulthood. Existing therapies largely address primarily positive symptoms (hallucinations and delusions), and the response to existing antipsychotic medications is highly variable, with approximately 30% of patients classified as treatment resistant. The lack of progress in therapeutic development is in part a consequence of the limited understanding of the molecular aetiology of psychiatric disorders.Recently, a number......
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, A nitric oxide-eluting and REDV peptide-conjugated coating promotes vascular healing
On 28 March 2022, Yunbing Wang, National Engineering Research Center for Biomaterials, Sichuan University, and his team published a paper tittled “A nitric oxide-eluting and REDV peptide-conjugated coating promotes vascular healing” in Biomaterials. They designed a bionic coating on vascular stents in a two-step manner to promote the healing of injured vessels by combining mussel-inspired molecular adhesion and a thiol-ene “click” reaction. The kits [ELISA Kit for Cyclic Guanosine Monophosphate (cGMP), CEA577Ge] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Drug-eluting stents (DESs) placement remarkably reduces the over-proliferation o......
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, New discovery of the pathological mechanism of alcoholic liver disease
Alcohol-associated liver disease (ALD) is a leading cause of liver injury resulting from chronic and abusive alcohol consumption. The spectrum of ALD ranges from alcoholic steatosis, to hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). A wide variety of host and environmental factors and comorbidities have been shown to modify the development and progression of ALD, including age, sex, genetic factors, drinking pattern, obesity, and chronic viral hepatitis.Despite major advances made in identifying potential pathways and therapeutic targets, there is no effective therapy besides abstinence. Uncovering novel molecular mechanisms of ALD pathogenesis that can lead to new......
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, Biomimic Trained Immunity-MSCs Delivery Microcarriers for Acute Liver Failure Regeneration
On 11 April 2022,Luoran Shang, Department of Hepatobiliary Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, and his team published a paper tittled “Biomimic Trained Immunity-MSCs Delivery Microcarriers for Acute Liver Failure Regeneration” in Small, which proposed a lipopolysaccharide (LPS)-loaded photoresponsive cryogel porous microcarrier (CPM) for MSCs delivery and colonization to promote defect liver regeneration.The kits [ELISA Kit for Lipopolysaccharide (LPS), SEB526Ge] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Mesenchymal stem cells (MSCs) have a demonstrated value for acute liver failure (ALF......
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, WWC proteins mediate LATS12 activation by Hippo kinases and imply a tumor suppression strategy
On April 15, 2022, Fa-Xing Yu, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, and hia team published a paper tittled “WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy” in Molecular Cell, which uncovered a molecular mechanism underlying LATS1/2 regulation and provided a strategy for treating diverse malignancies related to Hippo pathway dysregulation.The proteins [Recombinant WW And C2 Domain Containing Protein 3 (WWC3), RPU918Hu01] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.YAP and TAZ (YAP/TAZ), two major effectors of the Hippo signaling pathway, are freq......