Research into rejuvenation and life extension with the aim of developing relevant therapies is undergoing a renaissance.One such approach has been to leverage the four Yamanaka reprogramming factors to counteract the in vivo signs of aging and increase the lifespan of mice with a premature-aging disease. The concern, however, is that epigenetic reprogramming and its impact on rejuvenation could be notably attenuated or even lost in fully aged tissues owing to profound changes in the epigenome of old cells, persistent chronic inflammation, profound tissue fibrosis and other age-related debilitating conditions. Senescent cells as one of the key drivers of aging-induced tissue deteriorati......

The liver is an essential organ for maintaining normal life activities of the human body, because it not only regulates the metabolism of many nutrients and chemical drugs, but also has many functions such as synthesizing and decomposing proteins, regulating systemic blood volume, excluding body toxins, and regulating immunity. Based on the different etiologies and pathogenesis, liver diseases are classified as acute liver injury, viral hepatitis, alcoholic liver disease, metabolic-associated fatty liver disease, liver fibrosis, cirrhosis, and hepatocellular carcinoma. Due to the changes of living environment and the irregularity of life habits, the number of patients with liver diseas......

Esophageal cancer (EC) is the eighth most common cancer globally and has the sixth worst prognosis because of its aggressiveness and poor survival. The worldwide incidence of EC has been increasing over the past 3 decades, with some variation in the two main histological subtypes. Squamous cell carcinoma (SCC) is still the more common type of EC globally, with 79% of all SCC cases occurring in Asia . However, Western industrialized nations have experienced a rapid increase of esophageal adenocarcinoma (AC). EAC typically has a better overall median survival than ESCC, particularly in early stage disease. Despite countless improvements in diagnostic and treatment techniques over the pas......

Protein degradation is an emerging strategy to treat diseases, especially proteolysis targeting chimeras (PROTACs). PROTACs are heterobifunctional molecules that comprise a ligand targeting the protein of interest (POI), an element that recruits E3 ligases, and a linker connecting the above two moieties. Among them, the linker plays a critical role in bridging these two moieties. While many traditional linkers, including PEG, linear aliphatic chains, and more rigid (piperazine-type) linkers, have been studied, designing effective linkers remains challenging. Recently, DNA has been engineered to form DNA frameworks, such as DNA tetrahedra, octahedra, and icosahedra, with well-controlled......

On August 3, 2023,Wei Huang, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, China, and his team published a paper titled “Biomimetic multifunctional nanodrugs enable regulating abnormal tumor metabolism and amplifying PDT-induced immunotherapy for synergistically enhanced tumor ablation” in Materials Today. They reported a biomimetic multifunctional nanoparticle to regulate abnormal tumor metabolism and reverse immunosuppressive microenvironment for boosting anti-tumor immunotherapy.The kit [ELISA Kit for Interferon Gamma (IFNg)......

Obesity is a global, multifactorial disease defined as abnormal or excessive fat accumulation that presents a risk to health. Obesity is associated with several comorbidities, such as cardiovascular diseases (CVDs), metabolic syndrome, type 2 diabetes mellitus (T2DM)andcancer. Because of their increasing prevalence, significant impacts on health and medical costs, obesity with its comorbidities has become a public health concern. Traditionally, the cause of obesity is considered an imbalance between caloric intake and energy expended. Research has shown that a weight loss between 5% and 10% is enough to induce clinically relevant improvements in health risk factors such as raised blood......