Amphiregulin (AREG)

AR; CRDGF; SDGF; Colorectum Cell-Derived Growth Factor; Schwannoma-Derived Growth Factor

Amphiregulin (AREG)

Amphiregulin is a member of the EGF family of proteins. Amphiregulin is a major autocrine growth factor for cultured human keratinocytes and probably plays a role in the aberrant keratinocyte growth of hyperproliferative disorders.The protein encoded by this gene is a member of the epidermal growth factor family.

It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.Amphiregulin, also known as AREG.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)

Organism species: Oryctolagus cuniculus (Rabbit)

Organism species: Sus scrofa; Porcine (Pig)

Organism species: Bos taurus; Bovine (Cattle)

Organism species: Equus caballus; Equine (Horse)

Organism species: Chicken (Gallus)