Beta-Site APP Cleaving Enzyme 1 (bACE1)
ASP2; Beta Secretase; Memapsin 2; Aspartyl protease 2; Beta-site amyloid precursor protein cleaving enzyme 1; Membrane-associated aspartic protease 2
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β-Secretaseis an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein, contains two active site aspartate residues in its extracellular protein domain and may function as a dimer.Generation of the 40 or 42 amino acid-long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two sequential cleavages of the amyloid precursor protein (APP). Extracellular cleavage of APP by BACE releases a soluble extracellular fragment and is followed by APP cleavage within its transmembrane domain by γ-secretase. The second cleavage releases the intracellular domain of APP and amyloid-β. Since alpha-secretase cleaves APP closer to the cell membrane than BACE does.
Organism species: Homo sapiens (Human)
- Recombinant protein RPA718Hu01 Recombinant Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
- Polyclonal antibody PAA718Hu01 Polyclonal Antibody to Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
- Monoclonal antibody MAA718Hu22 Monoclonal Antibody to Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
- Monoclonal antibody MAA718Hu21 Monoclonal Antibody to Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
- Monoclonal antibody MAA718Hu23 Monoclonal Antibody to Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
- Monoclonal antibody MAA718Hu24 Monoclonal Antibody to Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
- Monoclonal antibody MAA718Hu25 Monoclonal Antibody to Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
- Sandwich ELISA SEA718Hu ELISA Kit for Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPA718Mu01 Recombinant Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
- Recombinant protein RPA718Mu02 Recombinant Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
- Polyclonal antibody PAA718Mu01 Polyclonal Antibody to Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
- Polyclonal antibody PAA718Mu02 Polyclonal Antibody to Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
- Sandwich ELISA SEA718Mu ELISA Kit for Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPA718Ra01 Recombinant Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
- Polyclonal antibody PAA718Ra01 Polyclonal Antibody to Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
- Monoclonal antibody MAA718Ra21 Monoclonal Antibody to Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock
- Sandwich ELISA SEA718Ra ELISA Kit for Beta-Site APP Cleaving Enzyme 1 (bACE1) In Stock