Cerebral Ischemia (CI)

Cerebral ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand.This leads to poor oxygen supply or cerebral hypoxia and thus to the death of brain tissue or cerebral infarction / ischemic stroke. Ischemia leads to alterations in brain metabolism, reduction in metabolic rates, and energy crisis. There are two types of ischemia: focal ischemia, which is confined to a specific region of the brain; and global ischemia, which encompasses wide areas of brain tissue. 

Model for cerebral ischemia are ideal model for discover therapeutic method for focal and global ischemia. Studies show that acetylsalicylic acid, estrogens makes neuroprotective effects in cerebral ischemia. NAD(+) administration decreases ischemic brain damage partially by blocking autophagy in a mouse model of brain ischemia.