Rat Model for Cerebral Ischemia (CI) Rattus norvegicus (Rat) Disease model

Brain Ischemia; Cerebrovascular Ischemia; MCAO

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceOcclusion of four blood vessels
  • Model Animal StrainsSD rats, male and female, weighing 250 ~ 300g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Rat Model for Cerebral Ischemia (CI) Packages (Simulation)
  • Rat Model for Cerebral Ischemia (CI) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

"SD rats, male and female, weight 250 ~ 300g, intraperitoneal injection of chloral hydrate (350 ~ 400 mg/kg weight agent or pentobarbital sodium (50 ~ 60 mg/kg body weight dose) after anesthesia, fixed in supine position, shave the neck hair, routine disinfection the skin on the surgery regional. The anterior median incision, isolated bilateral common carotid artery (CCA). At the same time cut open the occipital incision, seperate the exposed transverse process of the first cervical vertebra and left and right wing for transverse foramen by using microscope, set the hot electric iron tip inserted into the pterygoid hole, the appropriate depth is 2~3MM, electrocoagulation of bilateral vertebral artery (vertebral, artery, VA) cause the permanent occlusion, the insertion time should not be too long, 1 ~ 2S can avoid local heat too high to damage the spinal cord and brainstem. After 24h rats after light anesthesia with ether, neck routine sterilization, open the anterior median incision, will set the standby line in the bilateral common carotid artery ligation, according to the experiment needs it allows to block the flow for 10 ~ 60 min. The reperfusion can be performed after releasing the ligation.

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Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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