Apoptosis Signal Regulating Kinase 1 (ASK1)
MAP3-K5; MAP3K5; ASK1; MAPKKK5; MEKK5; Mitogen-Activated Protein Kinase Kinase Kinase 5; MAPK/ERK kinase kinase 5
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Apoptosis signal-regulating kinase 1 is an enzyme which in humans is encoded by the MAP3K5 gene. This gene is located on chromosome 6 at locus 6q22.33 and the transcribed protein contains 1,374 amino acids with 11 kinase subdomains. The ASK1 (MAPKKK5) protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; ASK1 does not activate MAPK/ERK.ASK1 found in the inactive form, bound to reduced thioredoxin.
When oxidized by a reactive oxygen species, Trx dissociates from ASK1. The ASK1, which is found as a homo-oligodimer, autophosphorylates and becomes an active MAP kinase kinase kinase.
Organism species: Homo sapiens (Human)
- Recombinant protein RPB358Hu01 Recombinant Apoptosis Signal Regulating Kinase 1 (ASK1) In Stock
- Polyclonal antibody PAB358Hu01 Polyclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) In Stock
- Monoclonal antibody MAB358Hu22 Monoclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) In Stock
- Sandwich ELISA SEB358Hu ELISA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPB358Mu01 Recombinant Apoptosis Signal Regulating Kinase 1 (ASK1) In Stock
- Polyclonal antibody PAB358Mu01 Polyclonal Antibody to Apoptosis Signal Regulating Kinase 1 (ASK1) In Stock
- Customized Service n/a CLIA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Apoptosis Signal Regulating Kinase 1 (ASK1) ELISA Kit Customized Service Offer