Cavia Model for Pruritus Cavia (Guinea pig ) Disease model

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by histamine phosphate injection
  • Model Animal StrainsGuinea pig, healthy, male and female, body weight 350g~700g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Cavia Model for Pruritus Packages (Simulation)
  • Cavia Model for Pruritus Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

2d before the experiment, cut off the guinea pig's right hind foot hair, remove the hair with the hair rmoval agent, about 1cm2, the day of the experiment, scratche gently the hair removal of the skin with a fine sandpaper , make it red, 30min after the scratch area, smear 0.05% phosphoric acid histamine <30ul / only), in 3min if the guinea pigs does not appear itching reaction, that is, after the right foot after the abrasion of the action, in the smear once histamine, repeat the operation until the itching reaction.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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