Cavia Model for Sensorineural Hearing Loss (SHL) Cavia (Guinea pig ) Disease model

SNHL

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by Acute or chronic otitis media
  • Model Animal StrainsGuinea pig, healthy, male and female, body weight 350g~700g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Cavia Model for Sensorineural Hearing Loss (SHL) Packages (Simulation)
  • Cavia Model for Sensorineural Hearing Loss (SHL) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Healthy ordinary grade variegated guinea pigs, male and female, weight 400 ~ 500g, ear augmentation sensitive, otoscopy to exclude the outer ear, middle ear inflammation. Methods The endotoxin lipopolysaccharide 1g/L. Under the microscope group, each animal was injected with E.coli lipopolysaccharide into the control group. The control group was injected with the same amount of saline. The auditory reflex and brainstem evoked potentials were measured before and after 1d, 10d, respectively. The animals were sacrificed and the anatomical otic tissues were fixed from the round window and the cochlea. The nitric oxide or 3% glutaraldehyde was fixed for cochlear patrol and electron microscopy scanning.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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