Mouse Model for Allergic Rhinitis (AR) Mus musculus (Mouse) Disease model

Hay fever

Add to Cart Distributors
Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by OVA sensitization and nasal drip method
  • Model Animal StrainsBalb/c Mice(SPF), healthy, male, age: 4~6weeks, body weight:18g~20g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and three Test drug group.
  • Modeling Period4-6 weeks
Share your citation Upload your experimental result Review Leave a message
Loading...

Share a new citation as an author

Upload your experimental result

Review

Please attach serial No. on instruction manual

Contact us

Please fill in the blank.

Name*
Organization
Address
E-mail address*
Telephone
Inquiry*
Verification code* CheckCode
  • Mouse Model for Allergic Rhinitis (AR) Packages (Simulation)
  • Mouse Model for Allergic Rhinitis (AR) Packages (Simulation)
  • DSI584Mu01.jpg Fig. Model mice of Allergic Rhinitis (AR)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

1.Preparation of sensitizer
Alum sensitizing adjuvant: After mixing 10% alum solution (dissolved in double distilled water) 2ml and 5% OVA (dissolved in PBS) 2ml, the PH was adjusted to 6.5 with NAOH, and the solution was incubated at room temperature for 60min. 750r/min, centrifuged for 5min, the supernatant was removed and redissolved in 2ml PBS. Each mouse was intraperitoneally injected with 200ul for sensitization.

2. Drug administration and modeling
0.2ml OVA suspension was intraperitoneally injected on days 1-11, respectively.

3. Nasal drip stimulation
Day 12-20, 40ul/ nostril nasal drops were given daily for 9 consecutive days.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

Recommend products