Mouse Model for Aplastic Anemia (AA) Mus musculus (Mouse) Disease model

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by busulfan aqueous solution
  • Model Animal StrainsBalb/c Mice(SPF), healthy, male, age: 8~10weeks, body weight:30g~35g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period45D+
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  • Mouse Model for Aplastic Anemia (AA) Packages (Simulation)
  • Mouse Model for Aplastic Anemia (AA) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

"Use distilled water to make Maryland 0.05% mixed suspension.make gavage with 4 ml/kg body weight dose for continuous 45 days. After 45 d, most of the nodel mice's peripheral blood leukocytes, platelets and hemoglobin are 1/3 more lower than normal mice.At the mean time,the number of femoral pluripotent hematopoietic stem cell is only about 40% of the normal mice. "

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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