• SPF
Mouse Model for Dysmnesia Mus musculus (Mouse) Disease model

Allomnesia; Memory impairment; Memory disorder

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by Drugs
  • Model Animal StrainsKM Mice(SPF), healthy, male, age: 4~6weeks, body weight:30g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period2-3 weeks
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  • Mouse Model for Dysmnesia Packages (Simulation)
  • Mouse Model for Dysmnesia Packages (Simulation)
  • DSI706Mu01.jpg Fig1.Morris test for mouse memory impairment
  • Mouse Model for Dysmnesia Fig2. Morris test for mouse Model for Memory impairment
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Memory impairment model: by intraperitoneal injection of Anisodine or scopolamine 5mg/kg 10min before training BW;
Memory consolidation barrier model: 10minbefore training, injected intraperitoneally with imide 120mg/kg BW;
Memory recall impairment model: 30% ethanol 10mL/kg BW intragastric, 30min before re-examination.

Model evaluation

Passive behavior test--- Dark avoidance test
Active behavioral test--- Morris water maze test

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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