Mouse Model for Glomerular Nephritis (GN) Mus musculus (Mouse) Disease model

Glomerulonephritis

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceNon-infectious Glomerulonephritis
  • Model Animal StrainsBalb/c Mice(SPF), healthy, male, age: 8~10weeks, body weight:30g~35g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Mouse Model for Glomerular Nephritis (GN) Packages (Simulation)
  • Mouse Model for Glomerular Nephritis (GN) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Weight of 18 ~ 20 g male KM mice, when,7,10 1 day according to the dose of 2 mg/mlPBS by intraperitoneal injection of sephadex gel suspension liquid 0.4 ml/time. Since 3 weeks, the mice tail antigen of dextran solution, given intravenously, 0.4 ml/time, 2 times a week, and the injection to 8 weeks continuously, 24 h after the last one antigen solution injection, bladder puncture mice, made of urine urine protein qualitative test. Animals bleeding to death after anesthesia, renal tissue samples for frozen section in mice, sheep with fluorescein isothiocyanate) mark against mice IgA direct fluorescent dye, on fluorescence microscope detection IgA antibodies. In kidney tissues, with 2.5% glutaraldehyde and 1% osmic acid, epoxy resin embedding, ultrathin slices, uranium acetate and lead citrate staining, were observed under tem.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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