Mouse Model for Hemopoietic Microenvironment Injury (HMI) Mus musculus (Mouse) Disease model

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by Co60γ Irradiate to nude mice
  • Model Animal StrainsBALB/c -nu/nu nude mice (SPF), 6 week, body weight: 18~22g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period3 weeks
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  • Mouse Model for Hemopoietic Microenvironment Injury (HMI) Packages (Simulation)
  • Mouse Model for Hemopoietic Microenvironment Injury (HMI) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

1. The gamma ray irradiation (Co60γ) with single dose of 3, 4, 5, 6, and 7 Gy was used to simulate the functional damage of the mild, moderate and severe hematopoietic microenvironment.
2. After irradiation, the general situation of the nude mice, the changes of hemogram, megakaryocyte count and the formation of the colony forming unit (colony forming unit-fibroblast, CFU-F) of bone marrow stromal cells were observed. The mortality of nude mice after irradiation in 21d was recorded and the survival rate was calculated.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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