Mouse Model for Leukopenia (LK) Mus musculus (Mouse) Disease model

Leukocytopenia; Leucopenia

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by Acute myelocytic leukemia cell culture medium suspension
  • Model Animal StrainsBalb/c Mice(SPF), healthy, male, age: 8~10weeks, body weight:30g~35g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Mouse Model for Leukopenia (LK) Packages (Simulation)
  • Mouse Model for Leukopenia (LK) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

"About 20 g weight, age male BALB/c mice for 8 weeks. In 1 000 r/min, the centrifugal acute single leukemia cell culture for 10 min, three times to supernatant after wash with physiological saline, adjust the concentration to 2 x 10 e9 / L by the mouse tail intravenous injection preparation has good cell suspension, 5 ml /. Only a day after inoculation survival days of observation model mice, in pursuance of a peripheral blood leukocyte counts, immature grain of mononuclear cells in mice original grain percentage and bone marrow mononuclear cells percentage, the bone marrow leukemia cells was observed under tem."

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±s), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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