Mouse Model for Myocardiosis Mus musculus (Mouse) Disease model

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceViral myocaditis induced by murine cytomegalovirus(MCMV)
  • Model Animal StrainsBalb/c Mice(SPF), healthy, male, age: 6~8weeks, body weight:25〜30g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group(low,medium,high).
  • Modeling Period4-6 weeks
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  • Mouse Model for Myocardiosis Packages (Simulation)
  • Mouse Model for Myocardiosis Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Use mouse with body weight of 25-30g, observe 3days then select the health animals to be modeled. The method is to inject diphtheria toxin solution into the tail vein of mice by 7.30ul/g body weight. 30 mins after injection, until the basic absorption of diphtheria toxin after injection. Observed indicators include: ① body temperature, 2 days before the start of the study of rectal temperature, measure 4 times every 4 hours after the diphtheria toxin, until death. ② Record every 6 hours for breathing, state of activity and food intake. ③ ECG, 2 days before the start of the experiment, twive every day. Methods: limbs and chest thorn a needle electrode. ④ heart pathology, each mouse after the death of the thoracic cavity to take out the heart to do pathological specimens, sections made of optical and electron microscopy. ⑤ death time, every hour to do an observation record.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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