Mouse Model for Myocardiosis Mus musculus (Mouse) Disease model

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceMyocarditis induced by diphtheria toxin
  • Model Animal StrainsBalb/c Mice(SPF), healthy, male, age: 4~6weeks, body weight:18g~20g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group(low,medium,high).
  • Modeling Period4-6 weeks
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  • Mouse Model for Myocardiosis Packages (Simulation)
  • Mouse Model for Myocardiosis Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Use the inbred mice with weight of 18 ~ 20g, age 4 ~ 6 weeks. The mice were intraperitoneally inoculated with 0.2ml of Coxsackie B3m virus (CVB3m, Nancy strain) to establish the severe Viral Myocarditis (VMC) model. Extract tissue samples after 1 week of inoculation. ①.Observe activity, food intake, body weight, coat color, and survival rate etc. ②.Observe the size, texture, color of the heart, liver and spleen. Weigh heart, liver and spleen / body weight (%) and thymus/body weight (%), heart/liver(%), heart/spleen(%), liver/spleen(%). ③.Pathological examination, take a piece of myocardial tissue, fix with 10% formaldehyde, conventional HE staining, observe the myocardial pathological changes.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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