Mouse Model for Periodontitis (PD) Mus musculus (Mouse) Disease model

Pyorrhea; Periodontal Disease

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Overview
Properties
  • Prototype SpeciesHuman
  • Sourceinduced by high sugar diet
  • Model Animal StrainsBalb/c Mice(SPF), healthy, male, age: 8~10weeks, body weight:30g~35g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Mouse Model for Periodontitis (PD) Packages (Simulation)
  • Mouse Model for Periodontitis (PD) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Feeding adult golden hamster with ingredients with Keyes 2000 formula (fructose 56%, 28% of flour, flour 6%, yeast 4%, alfalfa powder 3%, animal liver powder 1%, salt 2%) and a small amount of vegetables, 6 weeks later the microscopic pathological histological observation showed that there is the formation of periodontal pouch under epithelial cell proliferation to the enamel under the bone; inflammatory areas can be seen with white blood cell infiltration, increased vascular lacunae, bone surface osteoclasts also increased. Suggesting that Keyes 2000 formulations can form experimental periodontitis.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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