Mouse Model for Sinusitis Mus musculus (Mouse) Disease model

Nasosinusitis; Rhinosinusitis; Sinus infection

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceSource sex nasal sinus infection
  • Model Animal StrainsBalb/c Mice(SPF), healthy, male, age: 4~6weeks, body weight:18g~20g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Mouse Model for Sinusitis Packages (Simulation)
  • Mouse Model for Sinusitis Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

KM mice,male.Selecting type 3 pod models streptococcus pneumoniae, the bacteria after living in mice vaccinated two batches to increase its virulence, dispatch sterilized saline into the concentration of 1.2 X 109 CPU/ml of liquid. According to the dose of 150 mg/kg body weight by intramuscular injection of ketamine anesthesia. Each mouse into 4 drops per nostril bacteria liquid.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±s), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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