Mouse Model for Tubular Injury (TI) Mus musculus (Mouse) Disease model

KTD; Kidney Tubular Damage

No quotes Distributors
Overview
Properties
  • Prototype SpeciesHuman
  • Sourceinduced by Intravenous injection of mercury chloride
  • Model Animal StrainsBalb/c Mice(SPF), healthy, male, age: 8~10weeks, body weight:30g~35g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
Share your citation Upload your experimental result Review Leave a message
Loading...

Share a new citation as an author

Upload your experimental result

Review

Please attach serial No. on instruction manual

Contact us

Please fill in the blank.

Name*
Organization
Address
E-mail address*
Telephone
Inquiry*
Verification code* CheckCode
  • Mouse Model for Tubular Injury (TI) Packages (Simulation)
  • Mouse Model for Tubular Injury (TI) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Adult male mice weight 25 ~ 30 g, HgCl2 prepared with physiological saline as the solution of 0.125 g/L; The tail vein of mice by 10 ml/kg body weight dose injection HgCl2 solution. In the scheduled time of anesthesia posterior divisions arterial blood, serum creatinine and urea nitrogen determination; To be put to death animals quickly extract the kidney, saline wash, blot, part of the kidney tissues after processing measure renal lipid peroxide (LPO) and mercury, calcium, iron, zinc, copper and other trace elements; Take part after kidney purple fabric specimen fixed fluid, paraffin embedding, normal tissue section, HE stain, light microscopy observation.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

Recommend products