Porcine Model for Hypoxic Ischemic Encephalopathy (HIE) Sus scrofa; Porcine (Pig) Disease model

HIBD; NE; Hypoxic-ischemic brain damage; Neonatal encephalopathy

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceHypoxic-ischemic brain damage in the neonatal pigs
  • Model Animal StrainsPorcine, healthy, male and female, 3~4days, body weight 1000g~1500g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Porcine Model for Hypoxic Ischemic Encephalopathy (HIE) Packages (Simulation)
  • Porcine Model for Hypoxic Ischemic Encephalopathy (HIE) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Porket,3 to 4 days old, male and female, weight 1 ~ 1.5Kg. With 1% lidocaine after local anesthesia and ligation of the left carotid artery, and then placed in 8% oxygen and 92% nitrogen mixed gas confined Plastic box, during 1h, resulting in newborn pig ischemia and hypoxic brain damage.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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