Rabbit Model for Acute Pharyngitis (AP) Oryctolagus cuniculus (Rabbit) Disease model

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by nebulization
  • Model Animal StrainsBig ears white rabbit, healthy, male and female, weight 1.5-2.5kg.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Rabbit Model for Acute Pharyngitis (AP) Packages (Simulation)
  • Rabbit Model for Acute Pharyngitis (AP) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

2kg New Zealand rabbit.Every day, spray with 2. 5% ammonia animal pharyngeal 1 times in the moring and afternoon, each time with a throat spray 3 press, a total of 15 days. 8 days with a needle inject 0.5 ml turpentine tonsil under rabbit pharyngeal mucosa. Observe animal appearance state, every day and animal activity meter measure its activity; Every 1 day to observe one animal pharyngeal, including mucosal morphology, color and secretion. On side of 16th take animal ears when the venous blood for blood smear and determination of blood ammonia concentration, and then via femoral artery bleeding to death after animals, immediately remove the pharyngeal mucosa and the organization as a routine pathological biopsy and transmission electron microscopy (sem) specimens, were observed under light microscope and transmission electron microscopy (sem).

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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