Rabbit Model for Myocardiosis Oryctolagus cuniculus (Rabbit) Disease model

Cardiomyopathy

No quotes Distributors
Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by intraperitoneal injectionn of adriamyein
  • Model Animal StrainsJapanese white rabbit, healthy, male and female, weight 1.5-2.5kg.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group(low,medium,high).
  • Modeling Periodn/a
Share your citation Upload your experimental result Review Leave a message
Loading...

Share a new citation as an author

Upload your experimental result

Review

Please attach serial No. on instruction manual

Contact us

Please fill in the blank.

Name*
Organization
Address
E-mail address*
Telephone
Inquiry*
Verification code* CheckCode
  • Rabbit Model for Myocardiosis Packages (Simulation)
  • Rabbit Model for Myocardiosis Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Japanese big ear rabbit, weight 1.5 ~ 2.5 kg, age 3 ~ 4 months, inject the adriamycin veining the rabbit ear margin, 1 mg/kg each time, 2 times a week, a total of eight weeks, roughly equivalent to 320 mg / ㎡, adriamycin diluted with normal saline (NS) into 1 mg/ml. In order to avoid the heart adriamycin acute poisoning effect interference, after building to be put to death animals and part of the myocardial tissue for histological observation. (1) the determination of echocardiography: the determination of chest wall left cardiac structure and function of experimental animals. (2) the cardiac morphological observation: left ventricular myocardial tissue, 10% formaldehyde (formaldehyde) liquid fixed, paraffin embedding, 5 microns section, HE staining, the pathological changes were observed under light K.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

Recommend products