Rabbit Model for Sick Sinus Syndrome (SSS) Oryctolagus cuniculus (Rabbit) Disease model

Sinus dysfunction; Sinoatrial node disease

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by formaldehyde solution in sinoatrial node area
  • Model Animal StrainsNew Zealand rabbits, weight 2~2.5kg
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period1 day
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  • Rabbit Model for Sick Sinus Syndrome (SSS) Packages (Simulation)
  • Rabbit Model for Sick Sinus Syndrome (SSS) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

After the rabbits were anesthetized, separated the trachea, tracheal intubation and connected to the ventilator. Insertion of 4F four pacemaker from right external jugular vein to right atrium. Incision along the middle of the sternum, open the pericardium, exposing the right atrium and the superior vena cava.
2. In the sinus node position, topical sinus node area 3~5 min with 0.8 cm diameter filter paper dipped in 20% formaldehyde solution. Close monitoring of heart rate and rhythm.

Model evaluation

The success rate of the model was that the heart rate was reduced to 50% of the pre model and the occurrence of cumulative escape.

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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