Rat Model for Bladder Urolithiasis (BU) Rattus norvegicus (Rat) Disease model

Bladder stone

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by Phthalic acid
  • Model Animal StrainsWistar Rats(SPF), healthy, male and female, body weight 55g~60g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Rat Model for Bladder Urolithiasis (BU) Packages (Simulation)
  • Rat Model for Bladder Urolithiasis (BU) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Young rats weight 55 ~ 60 g, single cage. Adding 5% of standard rat feed phthalate (tcrephthalicacid, TPA), feed with the experiment in rats, continuous 14d, free drinking water. In 14d, with pentobarbital sodium anesthesia remove bladder after surgery, fixed in 10% methanol solution, for normal tissue section, HE stain and VonKossa's calcium staining display method, observed under optical microscope.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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