Rat Model for Cerebral Edema (CE) Rattus norvegicus (Rat) Disease model

Encephaledema

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by occlusion of common carotid artery
  • Model Animal StrainsSD rats (SPF class), Male, 6~8W, 200~250g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period2 d
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  • Rat Model for Cerebral Edema (CE) Packages (Simulation)
  • Rat Model for Cerebral Edema (CE) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

1. After anesthesia, the rats were exposed to the left and right common carotid arteries.
2. The left common carotid artery was ligated, and the right common carotid artery was interrupted intermittently for 3 times, every time for 15 mins, which resulted in ischemia reperfusion injury syndrome in order to establish brain edema model.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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