Rat Model for Cerebral Lacunar Infarction (CLI) Rattus norvegicus (Rat) Disease model

Lacunar infarction

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceCerebral lacunar infarction
  • Model Animal StrainsWistar Rats(SPF), healthy, male, body weight 180g~200g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Rat Model for Cerebral Lacunar Infarction (CLI) Packages (Simulation)
  • Rat Model for Cerebral Lacunar Infarction (CLI) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

"Chloral hydrate (350 ~ 400 mg/kg body weight dose) after anesthesia, cut off the neck hair, routine disinfection in operation area. Neck incision, right carotid, internal carotid and external carotid artery ligation, ipsilateral occipital artery, flat gland artery and pterygopalatine artery and external carotid artery distal end PE-50 catheter was inserted into the internal carotid artery, internal carotid artery to slow injection of sodium laurate 0.1ml solution containing 100 Mg, during the micro artery clamp temporary occlusion of the common carotid artery. After ligation of the internal carotid artery, suture of incision, wound disinfection and.After 48 h, 50 PE- after anesthesia animal catheter carotid artery second. Once injected with lauric acid sodium solution in the common carotid artery, then do the ligation of the common carotid artery."

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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