Rat Model for Congenital Diaphragmatic Hernia (CDH) Rattus norvegicus (Rat) Disease model

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by 2, 4-, two chloro phenyl -P- nitrobenzene ether ( Herbicidal ether)
  • Model Animal StrainsSD rats (SPF), female, pregnant for 9 days
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period3 weeks
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  • Rat Model for Congenital Diaphragmatic Hernia (CDH) Packages (Simulation)
  • Rat Model for Congenital Diaphragmatic Hernia (CDH) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

The 9 day of pregnancy in female rats were treated with tragastric administration of 100mg herbicidal ether (NI-TROFEN, 2, 4-, two chloro phenyl -P- nitrobenzene ether).
On the 21 day of pregnancy ，the embryos were removed by aseptic laparotomy,

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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