Rat Model for Dental Caries (DC) Rattus norvegicus (Rat) Disease model

Tooth decay; Cavities

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by injection of Streptococcus mutans into the oral cavity, combined with cariogenic diet
  • Model Animal StrainsSD rats (SPF), male, age: 5 weeks
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period10~12 weeks
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  • Rat Model for Dental Caries (DC) Packages (Simulation)
  • Rat Model for Dental Caries (DC) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

1. For 4 days, the BHI bacteria liquid (100ul/) of S.Mutans in the oral cavity of rats was given once a day, once in the morning, and the water was forbidden within 30mins after inoculation.
2. 41 days later, with the sterile scraping bamboo oral plaques, an anaerobic tank overnight culture, detect whether S.Mutans colonization. All rats were fed from 37 of the diet and fed a diet of 10% sucrose.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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