Rat Model for Embolic Cerebral Infarction (ECI) Rattus norvegicus (Rat) Disease model

ECI

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceMicroemboli suspension occlusion
  • Model Animal StrainsWistar Rats(SPF), healthy, male and female, body weight 180g~200g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Rat Model for Embolic Cerebral Infarction (ECI) Packages (Simulation)
  • Rat Model for Embolic Cerebral Infarction (ECI) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

The rats of both sexes, taking rat heart blood, put in the thrombosis placed at room temperature during 48h, using a syringe take out the blood clot then inject in the saline, repeated 3 times to form a small emboli suspension. 0.2ml (100 ~ 250um suction embolus) from common carotid artery (CCA), injection in the ICA,it can forme in the brain of multiple cerebral infarction.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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