Rat Model for Hypothyroidism Rattus norvegicus (Rat) Disease model

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by PTU
  • Model Animal StrainsWistar Rats(SPF), healthy,female, body weight 180g~200g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group(low,medium,high).
  • Modeling Period4-6 weeks
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  • Rat Model for Hypothyroidism Packages (Simulation)
  • Rat Model for Hypothyroidism Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Experimental pregnancy rats in 18 d, according to the dose of 25 mg / 100 g weight to fill the stomach through the mouth propylthiouracil (PTU), give medicine to young rats after weaning used in experiments.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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