Rat Model for Hypoxic Ischemic Encephalopathy (HIE) Rattus norvegicus (Rat) Disease model

HIBD; NE; Hypoxic-ischemic brain damage; Neonatal encephalopathy

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceHypoxic-ischemic brain damage in the neonatal rats
  • Model Animal StrainsSD rats, healthy, 7days, male and female, body weight >12g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Rat Model for Hypoxic Ischemic Encephalopathy (HIE) Packages (Simulation)
  • Rat Model for Hypoxic Ischemic Encephalopathy (HIE) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

"7-day-old SD rats, males and females, weight 12g. Inhalation of ether anesthesia, supine position, neck skin disinfection, neck incision, the left common carotid artery and 7-0 sterile silk line Ligation, and in the neck wound drip 2 ~ 3 drops of gentamicin, suture the wound and disinfect the skin after 30 min ~ 2 h rest, the rats are placed in plexiglass hypoxia chamber (30cmX40cmX50cm plexiglass cabin, two Side of the 1cmX 1cm hole connected with the outside world, one side of the nitrogen and oxygen mixture, the other side with the oxygen meter connected to the bottom with sodium lime to absorb CO2 and moisture), the import of nitrogen and oxygen mixed gas (oxygen: 8%, nitrogen: 92%). The cabin temperature was controlled at (36 +/- 1 degree, humidity (70 +/- 15)% and keep the hypoxia for 2 h. After the experiment, the rats were breastfed by the female rats, and the left common carotid artery was sutured directly in the sham operation group without ligating and entering the hypoxic chamber."

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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