Rat Model for Leukopenia (LK) Rattus norvegicus (Rat) Disease model

Leukocytopenia; Leucopenia

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by cyclophosphamide
  • Model Animal StrainsWistar Rats(SPF), healthy, male, body weight 180g~200g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Rat Model for Leukopenia (LK) Packages (Simulation)
  • Rat Model for Leukopenia (LK) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

"Weight about 150 g SD rats, according to the dose of 30 mg/kg body weight after the intraperitoneal injection of cyclophosphamide, continuous injection of 5 d. Model rats in drug delivery, drug delivery, 3, 5 days before and after drug withdrawal,5,8,11,15 2, respectively, in pursuance of a peripheral blood test, observe the total number of peripheral blood leukocytes. The last one test observation anesthesia executed after animals, take its femur, flush with Hanks liquid bone marrow cell, a microscope bone marrow nucleated cell count."

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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