Rat Model for Mammary Gland Hyperplasia (MGH) Rattus norvegicus (Rat) Disease model

Mammoplasia; Cyclomastopathy

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by benzoic acid estradiol and progesterone
  • Model Animal StrainsSD rats (SPF class), Female, 6~8W, 180~200g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period4~6 weeks
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  • Rat Model for Mammary Gland Hyperplasia (MGH) Packages (Simulation)
  • Rat Model for Mammary Gland Hyperplasia (MGH) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

1. Estradiol benzoic acid estradiol 0.5mg/kg/d was injected for 20 days with continuous hind leg muscles;
2. on the 21st day, progesterone 5mg/kg/d continuous hind leg muscle injection for 5 days, resulting in a rat model of hyperplasia of mammary glands

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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