Rat Model for Myocardiosis Rattus norvegicus (Rat) Disease model

Cardiomyopathy

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by intraperitoneal injectionn of adriamyein
  • Model Animal StrainsWistar Rats(SPF), healthy, half male and half female, body weight 170-200g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group(low,medium,high).
  • Modeling Periodn/a
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  • Rat Model for Myocardiosis Packages (Simulation)
  • Rat Model for Myocardiosis Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Use wistar rat with body weight of 170-200g. Intraperitoneal injection of doxorubicin with each dose of 2.5 mg/kg body weight. 3times per week, interval 2 weeks, then administration of 1 week, total 6 injections. The total dose is 15mg/kg. Observe 4 weeks after the completion of the injection. Use Cardiac function monitoring to monitor the cardiac function of normal rats and 4 weeks rats.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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