Rat Model for Neonatal Encephalopathy (NE) Rattus norvegicus (Rat) Disease model

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by fetal distress
  • Model Animal StrainsSPF SD female pregnant rats (21 days of pregnancy)
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period6 weeks
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  • Rat Model for Neonatal Encephalopathy (NE) Packages (Simulation)
  • Rat Model for Neonatal Encephalopathy (NE) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

1. Killed the pregnant rats(21 days of pregnancy), open the abdominal cavity, bilateral uterine horn with 4 hemostatic forceps. Cover the uterus with sterile gauze soaked in 37 degrees of normal saline to keep the local temperature and humidity of uterus. After 5 min, open the uterus immediately, remove the young rat, tear the fetal membrane, wipe the mouth and nose of newborn rats with dry cotton balls, then placed in 37 degrees constant temperature water bath box for warmth.
2. When the rats skin turned from pale pink, the body began to stretch, autonomous rhythmic breathing, as if in standard survival; if the body soft, color is white, can not breathe independently for death, to give up the rescue. The young rats were transferred to the suckling mice cage for 21 days.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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