Rat Model for Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) Rattus norvegicus (Rat) Disease model

OSA; Obstructive Sleep Apnea

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Overview
Properties
  • Prototype SpeciesHuman
  • Sourceinjection of sodium hyaluronate to palatoglossal arch, pharyngopalatine arch and tongue
  • Model Animal StrainsWistar Rats (SPF ), male, 200g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period1d~3d
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  • Rat Model for Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) Packages (Simulation)
  • Rat Model for Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

1. Anesthesia: pentobarbital sodium with sterile saline with 0.8% sodium pentobarbital solution. Intraperitoneal injection of different doses was performed during operation and sleep monitoring.
2. injection of sodium hyaluronate in rats after anesthesia, to the bilateral lingual palatal arch, pharyngopalatine arch and tongue till the rats appear apnea,
3. Acquisition of the signal: monitoring the electroencephalogram(EEG), electromyogram(EMG) and the muzzle flow (oro-nasal, AIRFLOW) of a patient with a modified multi - Sleep apparatus.
4. Analysis of signals: EEG, EMG, and muzzle airflow.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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