Rat Model for Osteoporosis (OP) Rattus norvegicus (Rat) Disease model

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by retinoic acid
  • Model Animal StrainsWistar Rats(SPF), healthy, male, body weight 180g~200g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Rat Model for Osteoporosis (OP) Packages (Simulation)
  • Rat Model for Osteoporosis (OP) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Each female rat of 3 months old is orally fed with retinoic acid at the dosage of 70 mg/kg for consecutive 14 d; later, such rats are fed with normal saline for the following 14 d. Animals are fed routinely and are allowed to drink water and eat food freely. Kill animals on the 29th day after modeling. Take their tibias and fix them in stationary liquid; later, these tibias are decalcified routinely and embedded in paraffin; then, take serial sections, which will be observed under light microscope.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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