Rat Model for Periodontitis (PD) Rattus norvegicus (Rat) Disease model

Pyorrhea; Periodontal Disease

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  • Prototype SpeciesHuman
  • Sourceinduced by Neck ligation
  • Model Animal StrainsSPF Wistar rats, the teeth were intact, without caries and periodontal abnormalities, healthy, male,
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period6 weeks
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  • Rat Model for Periodontitis (PD) Packages (Simulation)
  • Rat Model for Periodontitis (PD) Packages (Simulation)
  • DSI547Ra02.png Fig. ligatation of molar with orthodontic stainless steel wire
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

1. rats were anesthetized with intraperitoneal injection of 10% chloral hydrate (350mg/kg).
2. Dental probe separate first and second molar tooth gap, with the diameter of 0.2mm orthodontic stainless steel wire ligation of bilateral maxillary first molar tooth neck, with a needle holder holding a ligation wire into the rats from the bilateral maxillary first molars in the palatal, around the maxillary first molar after a week in the palatal side nearly at the fixed end of wire ligation, ligation of 3mm in subgingival retention back bend, prevent ligature scratch intraoral soft tissue, and no damage to the gingival junctional epithelium.
3. Close observation the state of rats after fed sugar water from the day of the experiment, sugar diet (drinking water was 10% glucose water, feed 10% glucose water immersion becomes routine diet soft)every day. Observe the condition of periodontal tissue and the periodontal every week after surgery.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±s), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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