Rat Model for Tubular Injury (TI) Rattus norvegicus (Rat) Disease model

KTD; Kidney Tubular Damage

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Overview
Properties
  • Prototype SpeciesHuman
  • Sourceinduced by Intraperitoneal injection of lead acetate
  • Model Animal StrainsWistar Rats(SPF), healthy, male and female, body weight 180g~200g.
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group.
  • Modeling Period4-6 weeks
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  • Rat Model for Tubular Injury (TI) Packages (Simulation)
  • Rat Model for Tubular Injury (TI) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

Male rats weight about 200 g, the abdominal cavity according to the dose of 5 mg/kg body weight 0.5% lead acetate injection, five times a week, a total of continuous injection of 12 weeks. 12 weeks after anesthesia animal models with bleeding to death, die before and during the process of model making, respectively quantitative determination of urine protein, urine lead excretion, renal renal function indexes, such as lead and glomerular filtration rate and put to death animals, in the scheduled time anesthesia in kidney tissue specimens, placed in fixed liquid, normal tissue section, HE stain, were observed under light. Electron microscopy (sem) specimens made of kidney tissues at the same time, were observed under tem.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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