Rat Model for White Matter Injury (WMI) Rattus norvegicus (Rat) Disease model

Brain white matter damage;

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Overview
Properties
  • Prototype SpeciesHuman
  • SourceInduced by ischemia-hypoxia
  • Model Animal StrainsNeonatal SD rats (SPF), 3 days old
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group and Test drug group
  • Modeling Period3 weeks
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  • Rat Model for White Matter Injury (WMI) Packages (Simulation)
  • Rat Model for White Matter Injury (WMI) Packages (Simulation)
  • Certificate ISO9001: 2008, ISO13485: 2003 Registered

Modeling Method

1. SD rats inhalation anesthesia with ether, supine position,after the iodophor disinfection, under the microscope in the neck to the right side of the trachea 0.5~1.0 cm longitudinal incision. The right common carotid artery was ligated with 7/0 suture line, and the artery was cut between the two ends of the ligation to prevent the ligation line from falling out, then suturing the incision, the epidermis was washed with normal saline.
2. After the operation, the newborn rats were placed in the hypoxic chamber 2 hours (n = 92% and the mixture of 8% oxygen). After the completion of the operation, return to the maternal side feeding.

Model evaluation

Pathological results

Cytokines level

Statistical analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison , P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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