Brain Derived Neurotrophic Factor (BDNF)

Neurotrophin; Abrineurin

Brain Derived Neurotrophic Factor (BDNF)

BDNF is a 13 kDa, 119 amino acid (aa) residue non-glycosylated polypeptide whose primary structure is conserved among all mammalian species examined. Initially synthesized as a 247 aa residue prepropeptide, the BDNF molecule is divided into an 18 aa residue signal sequence, a 110 aa residue prosequence, and a 119 aa residue mature segment.

Similar to other neurotrophic factors, there is a possibility that the N-terminus is alternatively spliced, giving rise to a longer pre-prosegment (but identical mature segment) with different functional properties. As a mature molecule, BDNF is 52% identical to NGF at the amino acid level, exists as a noncovalently-linked homodimer in solution, and contains six cysteine residues that are believed to form three intrachain disulfide linkages.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)

Organism species: Cavia (Guinea pig )

Organism species: Oryctolagus cuniculus (Rabbit)

Organism species: Canis familiaris; Canine (Dog)

Organism species: Sus scrofa; Porcine (Pig)

Organism species: Bos taurus; Bovine (Cattle)

Organism species: Capra hircus; Caprine (Goat)

Organism species: Ovis aries; Ovine (Sheep)

Organism species: Equus caballus; Equine (Horse)

Organism species: Chicken (Gallus)