Endothelin 1 (EDN1)

ET1; PPET1; Preproendothelin-1; Big endothelin-1

Endothelin 1 (EDN1)

Endothelin-1(ET-1), a peptide of 21 amino acid residues, is the most potent vasoconstrictive substance known. Originally isolated from porcine aortic endothelial cells, ET-1 is now known to be one of a family of three mammalian vasoactive peptides that also includes Endothelin-2 (ET-2) and Endothelin-3 (ET-3). These related peptides differ from ET-1 at two and six amino acid residue positions, respectively. A fourth peptide, vasoactive intestinal contractor (VIC), is sometimes classified as rat ET-2. All members of the endothelin family contain two essential disulfide bridges and six conserved amino acid residues at the C-terminus. Additionally, all of the endothelin family members are synthesized initially as prepropolypeptides of approximately 200 amino acid residues encoded by separate genes.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)

Organism species: Cavia (Guinea pig )

Organism species: Oryctolagus cuniculus (Rabbit)

Organism species: Rhesus monkey (Simian)

Organism species: Canis familiaris; Canine (Dog)

Organism species: Sus scrofa; Porcine (Pig)

Organism species: Capra hircus; Caprine (Goat)